They are tied up to the patient:

- Age group, because the advanced age decreases the inflammatory answer. 

- State Nutricional: the deficiency nutricional interferes in all the healing phases. 
The hipoproteinemy decreases the answer immunologic, the synthesis of collagen and the fagocytic function. 

- Chronic diseases: illnesses sistemic metabolic interference in the healing process.

- Therapy Associated: that interfere directly in the healing process. 
- anti-inflammatory
- antibiotics 
- esteroides 
- agents chemiotherapeutics.

Tensoactivy Soaps: it can have cytolic action affecting the membrane permeability. 

Antiseptic Solutions: it also has cytolic action. As larger concentration of the larger product will be the cytotoxicity affecting the healing process. This solution in contact with exudate and blood of the wound has its committed action.